Open call for submissions! The Canadian Nephrology Trials Network is planning our next virtual research symposium. Our network includes nephrologists, researchers and patient partners. This event is free and open to all. A great opportunity to present your work!
In collaboration with the University of South Australia, Drs. Bohm, MacRae, Thompson and Zimmerman and patient partner Nancy Verdin are conducting an international survey exploring exercise and physical activity practices and perceptions among peritoneal dialysis (PD) clinicians. The results will directly inform the development of exercise guidelines for people receiving PD.
The survey has been approved by the University of South Australia research ethics board, as it’s being conducted in collaboration with the Global Renal Exercise Network.
The survey has 13 questions and takes approximately 8 minutes to complete. Survey link HERE
A poster showcasing CNTN was available for view and to download at the recent Can-SOLVE CKD Network Annual Meeting September 9 and 10. The poster highlighted a timeline from inception to now, as well as highlighting our network goals, vision and what we offer. PDF version available here: CNTN Infographic PDF
The Capacity Building Committee and Communications and Engagement Committee are looking for additional members. These committees meet monthly for 1 hour to discuss ideas and move forward initiatives.
The Capacity Building Committee is focused on training and development of CNTN membership and the mentorship of new investigators and patient partners. Their mandate is to increase the number of people and resources available to conduct clinical trials in Canada and to increase the number of research ideas or questions developed by both patients and physicians.
The Communications and Engagement Committee’s mission is to increase the exposure of CNTN to the nephrology community across Canada thereby increasing membership to facilitate more collaboration with academic and non-academic sites across Canada and keeping that community informed about what is happening in the research community.
Email the CNTN project manager, Alicia at firstname.lastname@example.org, if you have questions or would like to join the committee.
In the most recent issue of the Canadian Medical Association Journal, Drs. Srinivas Murthy, Robert A. Fowler and Andreas Laupacis wrote an editorial about how the speed with which the UK executed the nation-wide priority-driven RECOVERY trial is not currently possible in Canada.
From the editorial: “Those who manage and fund Canada’s health care systems need to view high-priority trials as an integral part of clinical care and to provide adequate and stable infrastructure funding, thus avoiding the current time-consuming and expensive process of developing separate data-sharing agreements and contracts with many hospitals and organizations. ”
The comic was created by people with lived experience of suicide at the REFLECT research forum which brought together patients and caregivers as well as suicide prevention researchers, trainees and policy-makers.
The top 10 recommendations are:
Use common and clear language
Allow for customization to patient partner’s needs. Be flexible.
Be authentic in the approach to patient-oriented research. Avoid tokenism.
Define roles. Invite and acknowledge everyone’s contributions.
Balance power dynamics.
Invite patient partners to do more than what they are recruited for.
Compensate fairly and as a matter of course. Reimburse expenses.
Build relationships through honesty and trust.
Ensure governance through integrity and accountability.
Establish and encourage continuous communication and feedback.
Dr. Bhanu Prasad and his research team are conducting a feasibility study of a randomized controlled trial investigating renal denervation as a possible treatment option in patients with Loin Pain Hematuria Syndrome (LPHS). Dr. Prasad presented this study at the CNTN meeting in November 2019 in Washington, D.C and we look forward to hearing more about the study at future CNTN meetings.
Loin Pain Hematuria Syndrome (LPHS) is a poorly understood clinical condition characterized by severe pain localized to the kidney but in the absence of identifiable urinary tract disease. Case reports/series have shown renal denervation via catheter-based radiofrequency ablation to be an effective therapeutic option for the treatment of LPHS. To determine whether catheter-based renal denervation is a meaningful addition to the treatment options in these often difficult to treat LPHS patients, a randomized clinical trial is needed. Prior to conducting a definitive trial that focuses on patient outcomes, ensuring the feasibility of undertaking such a trial is required. As such, we will conduct a single-centre randomized control feasibility trial designed to determine viability and provide framework and direction for a larger trial.
The research team will conduct a double-blinded, parallel-group, partial crossover, sham-controlled, randomized feasibility trial on 10 LPHS patients at the Regina General Hospital, Saskatchewan. Participants will be randomized into either renal denervation (treatment group) or a sham treatment (control group). Data (pain, quality of life, mood, disability) will be collected from both groups at baseline, 6 weeks, 3 and 6 months after the intervention. After the initial 6-month follow-up is over, the participants who received the sham procedure will cross over into the treatment group and will be followed for an additional 6 months in the same manner as the treatment group.
The lessons learnt from this trial will lay the framework and direction for conducting a multi-site randomized controlled trial involving a larger cohort of patients.